Everything about ceesdekker.net
Everything about ceesdekker.net
Blog Article
‘The second is nanopores, which can be our oldest line of exploration and that has now led to DNA sequencers dependant on nanopores. We pull specific DNA strands through a nanopore and might then read from the nucleotide sequence. Very not long ago, we even managed to study out one protein for the first time working with this technique. But this line of investigation is not only about establishing tools, but in addition about serious biological inquiries.
It absolutely was only in the nineteen nineties although, when nanotechnology experienced Sophisticated to your level the place one molecules could possibly be manipulated, that the main experimental gadgets commenced to appear.
[Laughs] ‘It had been absolutely an incredible chance! At time, I was nicely conscious that it could go wrong Which I could come to be significantly less profitable, but I just dismissed that. Curiosity has usually been my strongest driving force. And fortunately everything worked out.’
Because 2000, Dekker has shifted the leading focus of his perform toward biophysics where he scientific studies the Attributes of one biomolecules and cells using the resources of nanotechnology. This variation of industry was driven by his fascination for your impressive performing of Organic molecular structures, in addition to with the extended-phrase point of view a large number of attention-grabbing discoveries may be anticipated In this particular subject.[5] Latest strains of investigate in his biophysics group are within the regions of:[six]
This yielded a breakthrough. Inside of only some months, we had been able to evaluate transportation by way of an individual solitary-walled carbon nanotube. Based on lower-temperature experiments by a brilliant PhD scholar in my group, Sander Tans (now a valued colleague and professor at Delft University of Technology using an Lively analysis lab at AMOLF in Amsterdam), we confirmed that carbon nanotubes have been legitimate quantum wires with really extensive (micrometres) electronic coherence lengths — confirming theoretical predictions of metallic behaviour.
Electrical transport in monolayers of phthalocyanine molecular wires and AFM imaging of only one wire bridging two electrodes
‘At the beginning we looked at biological devices with a physical look at and acted on The premise from the equipment we realized. It took a number of years prior to we commenced Doing the job much more on the large biological difficulties. I then began to call it nanobiology, a phrase that did not exist at time.
2011, initially in vitro measurements of transportation across an individual biomimetic nuclear pore sophisticated; advancement of multiplexed magnetic tweezers for kilo-molecule experiments; and settled the mechanism of homology recognition in DNA homologous recombination
2003, demonstrated the main biosensors built outside of a carbon nanotube; solved the framework and system of DNA fix proteins; and discovery of a fresh approach for fabricating sound-state nanopores for DNA translocation
Pretty awesome, but that wasn’t seriously exactly where my fascination lay. I needed to pioneer and I had the sensation which was no longer attainable, as the most fascinating basic insights experienced already been uncovered. But my area experienced produced quite a few exciting new equipment to evaluate individual molecules. I decided that I planned to utilize this to biology, to look at it from a physical perspective.’
In 1993 he was appointed as Associate Professor at Delft College of Technology. Inside the mid-nineteen nineties Dekker and his team reached success with the discovery with the Digital properties of carbon nanotubes, the primary one-molecule transistor and other nanoscience.
‘That fears the synthetic mobile, as Element of the Dutch BaSyC initiative. Craig Venter seemed major-down in These times and discovered about five hundred genes that happen to be minimally needed for the performing cell. We want to glimpse bottom-up: how cees dekker do we go from the couple of molecules to a whole Organic system?
Visualization of unstained DNA nanostructures with advanced in-concentrate transmission electron microscopy tactics
The biophysicist from Delft – who has been Probably the most cited experts during the Netherlands For several years – normally takes his duty to contribute into the rationalization and popularisation of his operate on the border of physics and biology very seriously and consistently seems within the media; Otherwise to look at his operate, then about the relationship concerning science and his Christian faith.